David Melodelima was awarded a PhD degree in Biomedical Engineering in 2004 from the university of Lyon, France for his work in the treatment of esophageal cancers using an intraluminal MR-guided High Intensity Focused Ultrasound (HIFU) device. He then carried out postdoctoral work in radiation force ultrasound elastography at Royal Marsden NHS Trust, Institute for Cancer Research, Sutton, UK. He was recruited by the French institute of Health and medical research (INSERM) in 2005 as a research scientist. He is now Research Director in the LabTAU (Laboratory of Therapeutic Applications of Ultrasound, Lyon, France) and head of the team “High Energy Ultrasound” with a teaching activity in the University of Lyon. His research covers the entire range of investigation of HIFU from the bench to the bedside with several clinical applications in the treatment of liver and pancreatic tumors. He is a member of the IEEE and ISTU societies, an associate editor of Scientific Reports and Editor-in-Chief of IRBM.