This talk will highlight advances in the use of image-guided focused ultrasound (FUS) as a non-invasive, multi-pronged interventional tool for potentiating multiple classes of immunotherapy, including vaccine adjuvants, checkpoint inhibitors, and CAR T cells. We will showcase integration of non-invasive surveillance approaches such as positron emission tomography (PET) and liquid biopsy with FUS to inform precision, adaptation, and de
intensification of combinatorial treatment regimens. We will also showcase development of novel image-guided ultrasound instrumentation toward these objectives. Applications spanning high-risk breast cancer and adult/pediatric brain cancers will be discussed. Finally, this talk will overview clinical translation and insights from first-in-human trials investigating FUS for immuno-oncology applications.
