Ultrasound-Based Multimodal Integrated Interventional and Wearable Platforms for Diagnosis and Treatment

To address this limitation, we developed ultrasound-based multimodal diagnosis-and-treatment platforms integrating optical and electrical modalities. By leveraging complementary contrast, penetration depth, and spatial resolution, these platforms enable comprehensive assessment of tissue structure, function, and molecular information, while supporting ultrasound-mediated targeted delivery and real-time treatment guidance. Based on these platforms, we developed an ultrasonic–optical–electrical interventional system for dynamic visualization and precise ablation of pancreaticobiliary lesions, an optical–ultrasonic wearable patch for continuous carotid monitoring, and an ultrasound-based in vivo targeted delivery system for functional carriers. Together, these studies establish multimodal interventional and wearable platforms that enable closed-loop coordination of multiscale diagnosis and multifunctional therapy, improving the precision and spatiotemporal synchronization of diagnosis and treatment.