The ARMPatch features glucose-responsive hydrogel microneedles that minimally penetrate the skin, swelling in response to glucose levels in interstitial fluid. Embedded silica microspheres enhance ultrasound contrast, enabling accurate, non-enzymatic glucose detection. In vitro and in vivo results demonstrate a strong, reversible correlation between microneedle swelling and glucose concentration, with stable and sensitive readings maintained for up to 56 days. Serving as an accessory to conventional ultrasound probes, the ARMPatch provides a minimally invasive, cost-effective, and durable solution for wearable CGM.
